Abstract
Background Prostaglandin D2 (PGD2) has long been implicated in allergic diseases such as asthma by contributing to bronchoconstriction, vasodilation, and vascular permeability. Recently, cloning of a second novel PGD2 receptor CRTh2, led to a greater understanding of the physiological and pathophysiological implications of PGD2. PGD2 signaling through DP1 and CRTh2 (DP2) mediates different and often opposite effects in many cell types of the immune system. Although mast cells (MC) are the largest source of PGD2 in the body, there is lack of information about their expression and the role of PGD2 receptors.
Highlights
Prostaglandin D2 (PGD2) has long been implicated in allergic diseases such as asthma by contributing to bronchoconstriction, vasodilation, and vascular permeability
Expression of a prostaglandin D2 receptor, CRTh2 on human mast cells and potential relevance in allergic diseases
PGD2 signaling through DP1 and CRTh2 (DP2) mediates different and often opposite effects in many cell types of the immune system
Summary
Expression of a prostaglandin D2 receptor, CRTh2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) on human mast cells and potential relevance in allergic diseases. From Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2010 Victoria, Canada. From Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2010 Victoria, Canada. 3-6 November 2010
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