Abstract
α-Synuclein was originally identified as the precursor of non-amyloid β component of Alzheimer’s disease amyloid (NAC). NAC is detected in cerebral amyloid angiopathy; and we studied whether cerebral vascular cells express α-synuclein. Immunohistochemical studies of normal human cerebral tissues revealed the expression of α-synuclein in vascular endothelial and smooth muscle cells. Also cultures of human umbilical vein endothelial cells and umbilical artery smooth muscle cells were found, by reverse transcription-polymerase chain reaction (RT-PCR) and Northern blot analysis, to constitutively express α-synuclein mRNA. Western blot analysis disclosed the presence of α-synuclein protein in lysates of these cells. We conclude that vascular cells express α-synuclein, and it may play some role in the physiology of the vascular wall.
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