Abstract
Background A number of researches focused on the study of tumors have concluded that the expression level of lncRNA NKILA was decreased in different tumors. This is an indication that NKILA might influence the start and growth of a cancer. In addition, studies have fatalities and worsening health of cancer patients is associated with a reduced level of NKILA. Results The results are the collective screening of nine total studies which included 937 cancer patients. The prognosis of the meta-analysis indicated that cancer patients with a higher expression of NKILA had an overall longer survival (OS) (HR = 0.808, 95% CI: 0.736, 0.887); with regard to the clinical prognosis, the results indicated that reduced NKILA was associated with advanced clinical stage (OR = 0.313, 95% CI: 0.225, 0.434), poor histological grades (OR = 0.833, 95% CI: 0.508, 1.367), positive lymph node metastasis (OR = 0.253, 95% CI: 0.144, 0.444), and additional tumor invasion depth (OR = 0.326, 95% CI: 0.234, 0.454). Materials and Methods Related research conducted was accessed by searching in PubMed and Web of Science with the keywords. The accessed material was till the 25th of February, 2020. The present quantitative meta-analysis was done using Stata SE12.0. The aim of the meta-analysis was to investigate the relationship between NKILA expression level and clinical prognosis. Conclusions In the result of this meta-analysis, decreased NKILA expression is typical of different kinds of cancer. Moreover, it can perform as a predictive element of prognosis in varied kinds of cancer. Nonetheless, till now, it is deemed essential to carry out larger-size as well as better designed research works for the confirmation of our findings.
Highlights
Long noncoding RNAs are involved in a number of physiological and pathological processes
Even though accurate mechanisms by which Long noncoding RNAs (lncRNAs) function has not been explained to date, research has indicated that a majority of the lncRNAs exhibit similar characteristics which are important such as proliferation [4], apoptosis [5], metastasis [6], metabolism [7], senescence [8], and drug resistance [9]
Two studies emphasised on hepatocellular carcinoma, one study was related to colorectal cancer, whilst one other emphasised on rectal cancer, whilst another study was associated with osteosarcoma
Summary
Long noncoding RNAs (lncRNAs) are involved in a number of physiological and pathological processes. Even though accurate mechanisms by which lncRNAs function has not been explained to date, research has indicated that a majority of the lncRNAs exhibit similar characteristics which are important such as proliferation [4], apoptosis [5], metastasis [6], metabolism [7], senescence [8], and drug resistance [9]. A number of researches focused on the study of tumors have concluded that the expression level of lncRNA NKILA was decreased in different tumors. This is an indication that NKILA might influence the start and growth of a cancer. Till it is deemed essential to carry out largersize as well as better designed research works for the confirmation of our findings
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