Abstract
BackgroundMany studies have reported that the expression level of lncRNA H19 was increased in various tumors. LncRNA H19 may play a significant role in cancer occurrence and development. An increased level of H19 was also associated with poor clinical outcomes of cancer patients.Results12 eligible studies were screened, with a total of 1437 cancer patients. From the results of meta-analysis, as for prognosis, the patients with high expression of lncRNA H19 were shorter in OS (HR=1.08, 95% CI: 1.05-1.12). Statistical significance was also showed in subgroup meta-analysis stratified by the cancer type, analysis type and sample size. In addition, the patients detected with high H19 expression may be poorer in DFS (HR=1.27; 95% CI = 0.97-1.56). As for clinicopathology, it showed that increased H19 was related to poor histological grades (OR=2.31, 95% CI: 1.12-4.75), positive lymph node metastasis (OR=2.29, 95 % CI: 1.21-4.34) and advanced clinical stage (OR=4.83, 95% CI: 3.16-7.39).Materials and MethodsEligible studies were collected by retrieving keywords in PubMed, Web of Science, Embase, CNKI and Wanfang database, from 1966 to April 23, 2016. This quantitative meta-analysis was performed with Stata SE12.0 and RevMan5.3 software. It aimed to explore the association between H19 expression level and prognosis and clinicopathology.ConclusionsLncRNA-H19 may be a novel molecular marker for predicting solid tumors. It can also be a predictive factor of clinicopathological features in various cancers. Further studies are needed to verify the clinical utility of H19 in human cancers.
Highlights
With the development of sequencing technique, it revealed that a majority of human genome was actively transcribed into noncoding RNAs
LncRNA-H19 may be a novel molecular marker for predicting solid tumors. It can be a predictive factor of clinicopathological features in various cancers
Further studies are needed to verify the clinical utility of H19 in human cancers
Summary
With the development of sequencing technique, it revealed that a majority of human genome was actively transcribed into noncoding RNAs (ncRNAs). Long noncoding RNAs (lncRNAs) was one type of ncRNAs, which attracted widespread interest and attention in current days [1, 2]. Many studies showed that lncRNAs play vital roles in diverse biological processes, as well as in disease mechanism [4–7]. In cancers, some lncRNAs were proved to act as tumor promoter or suppressor in the progress of tumorigenesis [8, 9]. It reported that dys-regulated expression of lncRNAs was involved in apoptosis, proliferation and invasion of cancer cells [10– 12]. Many studies have reported that the expression level of lncRNA H19 was increased in various tumors. LncRNA H19 may play a significant role in cancer occurrence and development. An increased level of H19 was associated with poor clinical outcomes of cancer patients
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