Abstract
To explore the prognostic potential of AK021443 in non-small-cell lung carcinoma (NSCLC), AK021443 levels in NSCLC specimens were determined by quantitative real-time polymerase chain reaction (qRT-PCR). The correlation between the AK021443 level and pathological factors in NSCLC patients was analyzed. Kaplan–Meier curves were plotted for assessing the prognostic value of AK021443 in NSCLC patients. Potential factors influencing NSCLC prognosis were analyzed by multivariable Cox regression test. AK021443 was upregulated in NSCLC specimens than normal ones. Its level was correlated to histological type, tumor differentiation, TNM staging, and lymphatic metastasis in NSCLC patients. AK021443 was the independent risk factor for the overall survival of NSCLC. AK021443 is highly expressed in NSCLC specimens, which is correlated to histological type, tumor differentiation, TNM staging, and lymphatic metastasis in NSCLC patients. It is the independent prognostic factor for NSCLC.
Highlights
Primary lung carcinoma is the most fatal tumor in the world
Correlation analysis between AK021443 and non-small-cell lung carcinoma (NSCLC) is rarely reported. In this Journal of Healthcare Engineering paper, we aimed to analyze the clinical significance of AK021443 in NSCLC patients, which provides a novel biomarker for clinical treatment
Overall survival (OS) was the primary endpoint, which was defined as the duration from the date of diagnosis to the date of death caused by any reason
Summary
Primary lung carcinoma is the most fatal tumor in the world. In 2015, up to 221,200 people were newly diagnosed as lung carcinoma, including 60% of deaths [1]. Non-small-cell lung carcinoma (NSCLC) is the major histological subtype, accounting for over 80% of total lung carcinoma cases [2]. The average survival of NSCLC is shorter than 6 months [3]. With the improvement of living habits and changes in lifestyle and dietary, the incidence of NSCLC shows an annual increase [4]. Molecular biology technologies have been largely progressed. E therapeutic efficacy of NSCLC, is not optimistic [5, 6] Molecular biology technologies have been largely progressed. e therapeutic efficacy of NSCLC, is not optimistic [5, 6]
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