Abstract
Objective To explore the expression of YKL-40 and vascular endothelial cell growth factor(VEGF) in condyloma acuminatum(CA) tissues and the related significance.Methods The expressions of YKL-40 and VEGF were analyzed by immunocytochemical staining with streptavidin-peroxidase(SP) in 33 CA tissues and 10 foreskin tissues of normal person.Results The expression intensities of YKL-40 and VEGF varied largely from positive(■) to strongly positive(■) in CA tissues compared with negative(-) and positive(+) in normal foreskin tissues.The expressions of YKL-40 and VEGF proteins in CA tissues were significantly different from those in the normal human controls(P0.05).No correlation was found between the expression of YKL-40 and VEGF proteins in CA tissues(r=0.27,P0.05),and their expressions were not correlated with other clinical factors(P0.05).Conclusion YKL-40 and VEGF are over-expressed in CA tissues,which may play a part in the occurrence and development of CA.
Published Version
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