Expression and significance of Ki67 and FHIT In adrenocortical tumor tissue

Abstract

[Objective] To study the relationship between Ki67, P16 and adrenocortical tumors. [Methods] The Labeling Index (LI) of Ki67 and P16 was detected by immunohistochemical staining in 68 cases of adrenocortical carcinoma(8 cases), adrenocortical adenoma (60 cases) and normal adrenocortical tissue beside tumor (9 cases). [Results] There is the highest expression of Ki67 and the lowest expression of P16 in adrenocortical carcinoma. There exist negative correlation between the expression of Ki67 and P16 (r=-0.7136,P 0.05). There is significant difference in the LI of Ki67 and that of P16 between adrenocortical carcinoma and adrenocortical adenoma (P 0.001 ). The cutpoint of LI of Ki67 was 4% and the cutpoint of LI of P16 was 12% in adrenocortical carcinoma. [Conclusions] The LI of Ki67 above 4% and LI of P16 below 12%,is a sensitive indicator of adrenocortical carcinoma. It is suggested that combine detecting the expression of Ki67 and P16 may be taken as one of biomarkers for differentiation of adrencortical adenomas from adrencortical carcinomas.