Abstract
Objective To explore the expression of P-glycoprotein(P-gp),topoisomerase Ⅱ alpha(TopoⅡα),P53 in primary hepatocellular carcinoma(PHC) and their correlations with clinical characteristics.Methods The expressions of P-gp,TopoⅡα and P53 were detected by means of SP immunohistochemical technique in 135 cases of PHC.Results The positive rates of P-gp,TopoⅡα and P53 were 80.74%(109/135),46.67%(63/135),33.33%(45/135) respectively.The positive rate of P-gp was higher than that of TopoⅡα or P53(P=0.000).The positive rate of TopoⅡα was higher than that of P53(P0.05).The expression of P-gp was related to age,tumor differentiation and tumor size.The expressions of P-gp and TopoⅡα were higher in cases with AFP-elevated than those of AFP-normal(P0.05).The expressions of P-gp and P53 were higher in cases with AST-elevated than those of AST-normal(P0.05).The expressions of TopoⅡα and P53 weren't related to age,tumor differentiation and tumor size(P0.05).The co-expression rate of multidrug resistant genes was 51.85%(70/135).The co-expression rate was higher than individual expression rate(34.07%,χ2=8.706,P0.01).Conclusion The multidrug resistance of PHC is affected by various multidrug resistance genes.There is synergistic effect between single and multiple genes,co-expression of multiple genes mainly.It is important that detection of their expressions may guide the clinical use of drugs and predicate chemotherapy effects.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
