Abstract
Objective To explore the expression of P-glycoprotein(P-gp),topoisomerase Ⅱ alpha(TopoⅡα),P53 in primary hepatocellular carcinoma(PHC) and their correlations with clinical characteristics.Methods The expressions of P-gp,TopoⅡα and P53 were detected by means of SP immunohistochemical technique in 135 cases of PHC.Results The positive rates of P-gp,TopoⅡα and P53 were 80.74%(109/135),46.67%(63/135),33.33%(45/135) respectively.The positive rate of P-gp was higher than that of TopoⅡα or P53(P=0.000).The positive rate of TopoⅡα was higher than that of P53(P0.05).The expression of P-gp was related to age,tumor differentiation and tumor size.The expressions of P-gp and TopoⅡα were higher in cases with AFP-elevated than those of AFP-normal(P0.05).The expressions of P-gp and P53 were higher in cases with AST-elevated than those of AST-normal(P0.05).The expressions of TopoⅡα and P53 weren't related to age,tumor differentiation and tumor size(P0.05).The co-expression rate of multidrug resistant genes was 51.85%(70/135).The co-expression rate was higher than individual expression rate(34.07%,χ2=8.706,P0.01).Conclusion The multidrug resistance of PHC is affected by various multidrug resistance genes.There is synergistic effect between single and multiple genes,co-expression of multiple genes mainly.It is important that detection of their expressions may guide the clinical use of drugs and predicate chemotherapy effects.
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