Abstract
To determine the clinical prediction role of the serum level of cyclooxygenase-2 (COX-2) and nuclear factor-κB (NF-κB) in papillary thyroid carcinoma (PTC) patients. 60 cases of PTC from February 2015 to May 2017 were collected to perform retrospective analysis and 10 patients with normal thyroid function were included as control group. We detected two immune factors: COX-2 and NF-κB in serum and analyse its relation to disease-free survival, overall survival, clinicopathological of PTC. COX-2 expression was associated with tumor tissue grade (p = 0.029), which was more abundant in III or IV stage (p = 0.087) patients. Relative to control group, PTC patients exhibited low NF-κB level. Survival analysis showed that the total survival time and disease-free survival time of low NF-κB level was shorter than that of control group (p < 0.05). Low COX-2 expression was associated with highly differentiated tumors (p = 0.015). However, COX-2 expression exerted little link with tumor grade, type, recurrent, age and clinical stage of PTC (p > 0.05).Further, regression analysis showed COX-2 and NF-κB expression is a risk factor for PTC, affecting prognosis. PTC patients exhibited low COX-2 and NF-κB expression, proving to correlate with the PTC development.
Highlights
Papillary thyroid carcinoma (PTC) refers to a conventional endocrine system tumor with gradually rising prevalence recently
Practical Application: The practical application statement: Our study shows that PTC patients exhibited low COX-2 and NFκB expression, proving to correlate with the PTC development
Low nuclear factor κB (NF-κB) level is related to tumorigenesis, which is an important manifestation and effective response to tumor growth and proliferation
Summary
Papillary thyroid carcinoma (PTC) refers to a conventional endocrine system tumor with gradually rising prevalence recently. Cyclooxygenase-2 (Cox2) exerted a positive correlation with tumor and inflammation, which can increase the specific expression and release various kinds of inflammatory factors by activating the immune response in vivo. Low nuclear factor κB (NF-κB) level is related to tumorigenesis, which is an important manifestation and effective response to tumor growth and proliferation. To further explore the biological manifestations of two factors in PTC is expected to play an important role in evaluating tumor harm. This topic aimed to analyze the expression of COX-2 and NF-κB in patients with PTC. We analyze important pathological features, tumor immune regulation and tumorigenesis to reveal its prognostic relevance to PTC. We aimed to evaluate whether it is a good predictor for early diagnosis, condition monitoring, and preoperative auxiliary diagnosis of PTC
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