Expression and clinical significance of small ubiquitin-like modifier-1 and P53 protein in uterine leiomyosarcoma

Abstract

Objective To learn the expression and significance of small ubiquitin-like modifier (SUMO)-1 and P53 protein in uterine leiomyosarcoma. Methods From March 2006 to March 2012, 20 cases of uterine leiomyosarcoma and 29 cases of uterine leiomyoma were collected. Immunohistochemical Envision method was used to detecte the expression level of SUMO-1 and P53 in 49 cases with uterine sarcoma, and prognosis was followed up by telephone in 20 cases of uterine leiomyosarcoma. Results The positive expression rates of SUMO-1 and P53 in uterine leiomyosarcoma were 85% and 30%, respectively; the positive expression rates of SUMO-1 and P53 in uterine leiomyoma were 52% and 0%, respectively; the positive expression rate of SUMO-1 in uterine leiomyosarcoma was significantly higher than that in uterine leiomyoma (P 0.05). Conclusion P53 may be implicated in the pathogenesis of uterine leiomyosarcoma and is useful in differentiating uterine leiomyosarcoma from uterine leiomyoma. SUMO-1 could be closely related to the occurrence of uterine leiomyosarcoma. Key words: Small ubiquitin-like modifier (SUMO)-1; P53; Uuterine leiomyoma; Uterine leiomyosarcoma; Immunohistochemistry