Application of CD10, desmin and vimentin in differential diagnosis of special types of uterine tumors

Abstract

Objective To study the application value of CD10, desmin and vimentin in the diagnosis and differential diagnosis of special types of uterine tumors. Methods The clinical data of 79 cases of special types of uterine cancer were retrospectively analyzed.CD10, desmin and vimentin were detected respectively by immunohistochemical streptavidin-perosidase(SP) method. Results The positive rates of CD10 in endometrial stromal sarcoma, epithelioid leiomyoma, atypical leiomyoma, leiomyosarcoma, carcinosarcoma were 76.2%, 0.0%, 13.3%, 30.8%, 75.0%, respectively.The positive rates of vimentin in endometrial stromal sarcoma, epithelioid leiomyoma, atypical leiomyoma, leiomyosarcoma, carcinosarcoma were 100.0%, 5.6%, 0.0%, 46.2%, 83.3%, respectively.The positive rates of desmin in endometrial stromal sarcoma, epithelioid leiomyoma, atypical leiomyoma, leiomyosarcoma, carcinosarcoma were 0.0%, 61.1%, 53.3%, 30.8%, 0.0%, respectively.The positive rates of vimentin and CD10 in endometrial stromal sarcoma and carcinosarcoma were all significantly higher than those in atypical leiomyoma, epithelioid leiomyoma(CD10: χ2=23.255, 13.829, 15.880, 8.102, all P=0.000; vimentin: χ2=35.159, 36.000, 15.556, 16.440, all P=0.000). The positive rates of desmin in atypical leiomyoma, epithelioid leiomyoma tissues were significantly higher than those in endometrial interstitial sarcomas, carcinosarcoma(χ2=11.480, 6.717, 17.875, 9.097, all P=0.000). Conclusion CD10, desmin and vimentin can be used as sensitive indicators for the differential diagnosis of uterine tumors with special types. Key words: Uterine neoplasms; CD10; Desmin; Vimentin; Diagnosis, differential