Expression and clinical significance of Pokemon and mdm2 proteins in gallbladder cancer

Abstract

Objective To investigate the relationship between POK erythroid myeloid ontogenic factor (Pokemon) and mdm2 proteins expressions and gallbladder cancer and its clinical significance.Methods The Pokemon and mdm2 proteins were analyzed in 40 gallbladder cancer patients,12 gallbladder adenoma patients,20 gallbladder polyps patients and 20 chronic cholecystitis patients.The relationship between the expressions of Pokemon and mdm2 and clinic-pathological features of gallbladder cancer were analyzed.The correlation of Pokemon expression with mdm2 expression in tissues was analyzed as well.Results In the tissues of gallbladder cancer,gallbladder adenoma,gallbladder polyps and chronic cholecystitis,the positive expression rates of Pokemon protein were 60.0％,25.0％,30.0％,25.0％,the positive expression rates of mdm2 were 57.5％,16.7％,35.0％,30.0％.The positive expression rates of Pokemon and mdm2 in gallbladder cancer tissues were higher than those in other group,and there were significant differences (P ＜ 0.05 ).In gallbladder cancer tissues,the positive expression rates of Pokemon and mdm2 protein were correlated with different stage and grade of the tumor tissues ( P ＜ 0.05 ),and there was a positive correlation of the expression of Pokemon with mdm2 (r =0.434,P ＜0.05).Conclusions Pokemon and mdm2 proteins may be involved in the genesis,development and metastasis of gallbladder cancer.The Pokemon may be a target gene in gallbladder cancer threapy. Key words: Gallbladder cancer; Pokemon; mdm2; Immunohistochemistry