Abstract
Objective To investigate the expression and clinical significance of astrocyte elevated gene-1 (AEG-1) and vascular endothelial growth factor (VEGF) in cholangiocarcinoma.Methods The expression levels of AEG-1 and VEGF in bile duct neoplasms were detected by using immunohistochemistry,including 112 cases of malignant tumors and 29 cases of benign tissues.Results The positive expression rate of AEG-1 and VEGF was respectively 71.4％ and 70.5％ in malignant tumors,higher than 0％ in benign tissues (P ＜0.01).The positive expression rate of AEG-1 was positively associated with histological classification (well-differentiated 45.5％,moderately differentiated 64.9％,and poorly differentiated 86.8％),clinical stage (stage Ⅰ-Ⅱ 61.8％,stage Ⅲ-Ⅳ a 91.7％) and lymph node metastasis (positive lymph node metastasis 61.8％,and negative lymph node metastasis 91.7％) (P ＜ 0.05),but not with ages and pathologic types (P ＞ 0.05).Conclusion Overexpression of AEG-1 and VEGF in cholangiocarcinoma suggests poor prognosis.They can be used as detection indexes to evaluate prognosis. Key words: Cholangiocarcinoma; Astrocyte elevated gene-1; Vascular endothelial growth factor
Published Version
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