Expression and Clinical Significance of Annexin-1 in Lung Squamous Carcinoma Tissues

Abstract

Objective To investigate the expression and significance of Annexin-1(Anx-A1) mRNA and protein in lung squamous carcinoma tissues.Methods Quantitative real-time PCR(qRT-PCR) and Western blot were used to detect Anx-A1 mRNA and protein levels in 22 cases of lung squamous carcinoma and corresponding adjacent normal tissues.The relationship between expressional levels and pathological characters was analyzed.Results The expression levels of Anx-A1 mRNA and protein in lung squamous carcinoma were significantly higher than those in adjacent normal tissues.The expression level of Anx-A1 in poor differentiated tissues was higher than that in middle and high differentiation tissues of lung squamous cell carcinoma(P0.05).No expression difference between stage Ⅲ tumor tissues and stageⅠ～Ⅱ tissues was detected(P0.05).Conclusion Up-regulated expressions of Anx-A1 mRNA and protein in lung squamous cell carcinoma tissue might contribute to lung carcinogenesis.