Abstract
Objective To investigate the expression and significance of Annexin-1(Anx-A1) mRNA and protein in lung squamous carcinoma tissues.Methods Quantitative real-time PCR(qRT-PCR) and Western blot were used to detect Anx-A1 mRNA and protein levels in 22 cases of lung squamous carcinoma and corresponding adjacent normal tissues.The relationship between expressional levels and pathological characters was analyzed.Results The expression levels of Anx-A1 mRNA and protein in lung squamous carcinoma were significantly higher than those in adjacent normal tissues.The expression level of Anx-A1 in poor differentiated tissues was higher than that in middle and high differentiation tissues of lung squamous cell carcinoma(P0.05).No expression difference between stage Ⅲ tumor tissues and stageⅠ～Ⅱ tissues was detected(P0.05).Conclusion Up-regulated expressions of Anx-A1 mRNA and protein in lung squamous cell carcinoma tissue might contribute to lung carcinogenesis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
