Abstract
Objective To investigate the expression of thymidine kinase 1 (TK1) and snail in non-small cell lung carcinoma (NSCLC), and their correlation with the clinicopathological features. Methods Envision immunohistochemical method was used to assess the expression of TK1 and Snail in 87 cases of human NSCLC tissues and non-cancerous adjacent lung tissues. Results The expression rate of TK1 in breast carcinoma tissues was higher than that of non-cancerous adjacent breast tissues (71.26% vs. 21.84%, P<0.01). The expression rate of Snail in breast carcinoma tissues was higher than that of non-cancerous adjacent breast tissues (85.06% vs. 18.39%, P<0.01). The expression levels of TK1 were correlated histologic grade, TNM stage and lymph node metastasis of NSCLC (P<0.05). There was a close correlation between the expression of Snail and histologic grade and TNM stage (P<0.05). Conclusion TK1 and Snail may participate in the development and progression of NSCLC, and may be used to provide information for predicting prognosis of patients with NSCLC. Key words: Non-small cell lung carcinoma; Thymidine Kinase 1; Snail; Immunohistochemical method
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