Expression and bioinformatic analysis of C1QBP in non-small cell lung cancer

Abstract

Objective It has been proven that complement component 1q subcomponent binding protein (C1QBP) might play an important role in the oncogenesis and progression of numerous malignant tumors.The aim of this study is to evaluate the relationship between C1QBP and non-small cell lung cancer. Methods The expression of C1QBP was detected by immunohistochemical method in 46 cases of non-small cell lung cancer and 24 cases of normal lung tissue in the Second Affiliated Hospital of Xi′an Jiaotong University.TNM stage, lymph node metastasis, cell differentiation and expression of C1QBP were evaluated.The bioinformatic of C1QBP were analyzed. Results The expression of C1QBP was significantly higher in NSCLC tissues than that in normal lung tissues (P<0.05). The strength of positive expression was not correlated with the gender, age, TNM stages, lymph node metastasis and histological type, and was correlated with the degree of tumor differentiation.Bioinformatic analysis suggested that C1QBP was mainly located in the mitochondria and has MAM33 domain.C1QBP plays a certain role in signal transduction, stress response and immune response.The KNG1 protein screened by the STRING database interacts with C1QBP. Conclusions C1QBP may play an important role in the oncogenesis of NSCLC.C1QBP may be a novel biomarker for the diagnosis of NSCLC and a new target for its treatment. Key words: Lung Neoplasms; Immunohistochemistry; Computational Biology; Complement component 1q subcomponent-binding protein