Abstract
Objective To study the expression and significance of P33/ING1 and HIF-1α in invasive ductal carcinoma of breast(IDC).Methods Immunohistochemical SP method was performed to detect the expression of P33/ING1 and HIF-1α in 68 cases of IDC and 20 cases of breast fibroadenoma and the relationship between the expression and clinical-pathological characteristics was analyzed.Results The positive expression rates of P33/ING1 protein in IDC was significant lower than that in breast fibroadenoma(60.29% vs.95%;P0.01);and negatively correlated with tumor size,axillary lymph node metastasis and histologic grade(P0.05).The positive expression rates of HIF-1α protein in IDC was significant higher than that in breast fibroadenoma(52.94% vs.10%;P0.01) and positively correlated with axillary lymph node metastasis and histologic grade(P0.05).There was a negatively correlation between P33/ING1 and HIF-1α in IDC(r=-0.283;P0.05).Conclusion There were low-expression of P33/ING1 and over-expression of HIF-1α in IDC.P33/ING1 and HIF-1α proteins were significantly correlated with the clinicopathological characteristics in IDC.Combined detection of P33/ING1 and HIF-1α might calculate the biological behaviors of IDC.
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