Expression of Cullin7 in breast invasive ductal carcinoma and its clinical significance

Abstract

Objective To explore the expression of Cullin7 protein in breast invasive ductal carcinoma and its relationship with the clinicopathological factors.Methods The expression of Cullin7 protein was detected in 13 cases of normal breast tissues,20 cases of benign breast tumor,68 cases of breast cancer and 32 cases of axillary lymph node metastasis of breast cancer tissue samples by immunohistochemical streptavid-in-peroxidase (SP) method.Results The positive expression rate of Cullin7 in normal breast tissue,benign breast tumor,breast invasive ductal carcinoma and axillary lymph node metastases of breast cancer was 0,30.0％,55.9％,and 78.1％ respectively.The positive expression rate of Cullin7 in the axillary lymph node metastases of breast cancer was significantly higher than the other three kinds of tissue samples (P ＜ 0.05).Cullin7 protein expression had no obvious correlation with the menopausal status,tumor size,clinical stage or pathological type P ＞ 0.05),but had a significant correlation with tissue differentiation degree and axillary lymph node metastasis (P ＜ 0.05).Cullin7 protein expression in breast cancer tissue was significantly negatively correlated with estrogen receptor (ER,P ＜ 0.05),but not with progesterone receptor (PR),and human epidermalgrowth factor receptor-2 (Her-2,P ＞ 0.05).Conclusion Cullin7 may play an important role in the development,invasion and metastasis of breast cancer. Key words: Breast carcinoma ; Transfer; Cullin7