Abstract
In breast cancer there are prognostic and predictive factors that can affect the evolution of women with breast cancer. For this reason, the present study aims to determine the immunohistochemical expression (IHC) of p53 and Bcl-2 proteins in the primary tumor of 285 women with a diagnosis of infiltrating ductal carcinoma of the breast under follow-up at the Dr. Miguel Oncology Institute. Perez Carreno from Valencia, Venezuela. The immunoexpres-sion of both proteins was related to the molecular intrinsic subtypes of breast cancer defined by IHC: Luminal A, Luminal B, HER2 and Triple Negative (TN), disease free survival (SLE) and overall survival (OS). The tumors p53 negative and Bcl-2 positive showed a higher SLE and SG. In the p53 negative tumors of the Luminal A subtype there was a higher SLE (p = 0.005), although in the Luminal tumors (A and B) the OS was higher with p <0.05. In addition, greater SLE was presented in Luminal and TN cases with positive Bcl-2 expression, but without statistical significance. On the contrary, there was a significant prognostic effect of the expression of Bcl-2 in the TN subtype, with a lower mean SG compared to the SG obtained in tumors with positive Bcl-2. Finally, based on the findings found, the absence of p53 expression and the positive expression of Bcl-2 are good prognostic factors, with statistical significance in Luminal and TN tumors, respectively.
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