Abstract
Nanosecond electric pulses have been successfully used as a novel electrical stimulus for evoking a dependent catecholamine release from the bovine adrenal chromaffin cells. It was observed that the duration of calcium influx varies depending on the exposure system. For example, cells exposed to 5 ns and 5MV/m pulses by a gold strip exposure chamber elicited calcium responses similar to the physiological stimulus, nicotinic cholinergic receptor activation. On the other hand, recent exposure systems utilizing tungsten rod electrodes evoke an undesired calcium response that is relatively long-lived even by exposure of the same pulse.
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