Abstract
Exposition of Uranium Modulates of the Expression of Cyps and Transporters Involved in Cholesterol Metabolism in Rat Liver
Highlights
Cytochromes P450 are key enzymes for the conversion of cholesterol into bile acids that occurs in the liver [1]
The liver is the key organ for cholesterol homeostasis at body level because of its central role in lipoprotein metabolism and of its unique ability to eliminate the excess cholesterol through the biosynthesis of bile acids
This paper presents the effects on cholesterol metabolism in rats ingesting a low dose of depleted uranium (DU) for 9 months
Summary
Cytochromes P450 are key enzymes for the conversion of cholesterol into bile acids that occurs in the liver [1]. CYP7B1 is involved in the acidic pathway, whereas CYP8B1 is common to both pathways and controls the ratio hydrophylic: hydrophobic bile acids Another CYP is involved with cholesterol: CYP51, which belongs to the biosynthesis pathway. The mRNA levels of several actors of the cholesterol transport system were increased (SR-B1, ABC A1, ApoE) after chronic ingestion. These previous results highlight the fact that DU can modulate cholesterol metabolism in the brain, which is independent from the rest of the body in this respect. The liver is the key organ for cholesterol homeostasis at body level because of its central role in lipoprotein metabolism and of its unique ability to eliminate the excess cholesterol through the biosynthesis of bile acids. In addition to this, depleted uranium has been shown to accumulate in the liver [4], where it can exert both its chemical and radiological toxicity
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