Abstract
The explosive and explodibility parameters of a new organic nitrate drug, ITF 296, have been studied. ITF 296 does not possess explosive properties, as determined by European Community standard testing methods (heat, impact and friction tests). The decomposition and auto-ignition temperature, determined by differential scanning calorimetry, are substantially higher than the working temperature which can be achieved with this compound. However, the explodibility properties of ITF 296, as determined by a hot-wire ignition method (Hartmann modified apparatus) and a heat oven auto-ignition method, place ITF 296 in Dust Hazard Class I. The addition of anhydrous dibasic calcium phosphate strongly attenuates the explodability properties of ITF 296 and, consequently, the need for expensive anti-explosion measures in the development and production environment.
Published Version
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