Abstract
Biological membranes of many tissues contain channels with large pores that permeate a wide variety of ions and metabolites. Examples include the connexin, innexin, pannexin and the calcium homeostasis modulator protein (CALHM) families. To maintain cell viability, it is critical for the gating and permeability of these big pores to be tightly regulated. Structural information on pannexins and CALHMs, and hence an understanding of the molecular mechanisms that underpin their channel activities in a structural context had been completely lacking at the beginning of this project.
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