Exploring the potential of xanthene derivatives for antitubercular activity

Chitre Ts,Khedkar Vm,Sarkar D,Asgaonkar Kd,Shurpali K,Dube As,Jha Pc,Kathiravan M

doi:10.15761/gdt.1000129

Abstract

Exploring the potential of xanthene derivatives for antitubercular activity

Highlights

Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is a global public health problem [1]
Efficiency against active as well as dormant forms are some of the criterions for development of new drugs for tuberculosis [3]
In an attempt to further explore the tricyclic dibenzopyrans scaffold, we have previously reported efficient synthesis of few xanthenes derivatives as shown in Figure 1 and Table 1 [6]

Summary

Introduction

Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is a global public health problem [1]. The control of the disease is often compromised due to serious side effects of currently available antitubercular drugs and emergence of resistant strains of MTB [2]. Various pharmacological activities have been reported for the heterocyclic scaffold of tricyclic dibenzopyrans, viz., xanthenes [5]. In an attempt to further explore the tricyclic dibenzopyrans scaffold, we have previously reported efficient synthesis of few xanthenes derivatives as shown in Figure 1 and Table 1 [6]. In continuation of our efforts in antitubercular research [9,10] and having considered the structural similarity of these two tricyclic dibenzopyrans viz., xanthene derivatives synthesized by us and the reported antimycobacterial and immunomodulatory xanthone derivatives, the synthesized derivatives have been investigated for the antimycobacterial and immunomodulatory activities. To gain insight into the probable mechanism of action or binding mode of these xanthene derivatives, the title compounds have been docked into the active site of TMPKmt

Results and discussion

Result

Results

Conclusion