Exploring the mechanism of quercetin on cervical cancer based on network pharmacology and molecular docking

Abstract

Cervical cancer is one of the major cancers that endanger women's lives. At present, the means of treatment are still limited. Traditional Chinese medicine and its ingredients, as a new direction, provide new ideas for the treatment of cervical cancer. Quercetin, as the main ingredient in many traditional Chinese medicines, may be a new ingredient in the treatment of cervical cancer. Based on network pharmacology and molecular docking technology, this paper analyzes the mechanism of quercetin in the treatment of cervical cancer, and further explores the modern pharmacological action of quercetin. The related targets of "quercetin" were screened from the TCMSP database; Relevant targets of "cervical cancer" were screened from Genecards database. After the common protein target information of the two was obtained through venny, the protein interaction network was constructed using Cytoscape software, and the hub gene was screened. Use David platform to conduct GO, KEGG and other enrichment analysis on the same target. Finally, molecular docking technology was used to test the accuracy.There are 128 nodes and 911 edges in the PPI network, among which AKT1, TNF, JUN, TP53, IL-6, VEGFA, EGFR, RELA, CASP3 and other targets rank higher. The enrichment analysis results of GO and KEGG showed that the effect of quercetin on cervical cancer mainly involves biological processes such as positive regulation of gene expression, response to drug, positive regulation of translation, DNA-template, etc. The signal path mainly includes AGE-RAGE signaling path in radial applications, TNF signaling path, IL-17 signaling path, etc. Molecular docking results show that quercetin is associated with AKT1, TP53, TNF- α The binding degree of iso-target and quercetin is good. It is enriched in KEGG pathway. It reveals the potential target and mechanism of quercetin acting on cervical cancer, hoping to develop new drugs for treating cervical cancer.