Abstract
T cell activation is a key event in adaptive immunity. However, the dynamics and influencing factors of Tcell activation remain unclear. Here, we analyzed CD4 Tcells that were stimulated with anti-CD3/CD28 under several conditions to explore the factors affecting Tcell activation. We found a stimulated T subset (HSPhi T) highly expressing heat shock proteins, which was derived from stimulated naive T. We identified and characterized inert T, a stimulated Tcell subset in transitional state from resting T to activated T. Interestingly, resting CXCR4low T responded to stimulation more efficiently than resting CXCR4hi T. Furthermore, stimulation of CD4T in the presence of CD8T resulted in more effector T and more homogeneous expressions of CD25, supporting that presence of CD8T reduces the extreme response of Tcells, which can be explained by regulation of CD4T activation through CD8 T-initiated cytokine signaling and FAS/FASLG signaling.
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