Abstract
Objectives: This research investigates the potential antidepressant properties of raspberry ketone (RK) using a chronic unpredictable mild stress-induced depression model in mice. Materials and Methods: Through a comprehensive examination encompassing behavioural and neurochemical assessments, the study reveals promising outcomes. RK administration results in significant enhancements in locomotor activity, reductions in immobility time and improvements in sucrose preference, indicative of antidepressant-like effects. Results: RK treatment leads to elevated levels of dopamine and serotonin, coupled with a decrease in inflammatory cytokines, suggesting a multifaceted mechanism underlying its therapeutic potential. Conclusion: These findings underscore the promise of RK as a novel antidepressant agent, with implications for developing alternative and potentially more tolerable treatments for depression. Further, exploration into its mechanisms and clinical applicability is warranted.
Published Version
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