Abstract
Abstract Exploring Stem Cells: The Role of Stem Cells in Immune System Function is an educational unit developed for high school life science courses. Students will learn about embryonic and adult stem cells and the role adult stem cells play in the Immune System's function. Students will learn about the tendency of Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) patients to develop premature cardiovascular disease, specifically atherosclerosis. The unit will explore how the body's immune system, through the production of interferon αmay interfere with the normal development of endothelial progenitor cells (EPCs). Interferons are cytokines that are involved in immune system regulation and the inflammatory response. EPCs are bone marrow-derived stem cells which circulate in the bloodstream and participate in endothelial repair of the lining of blood vessels of the cardiovascular system. This 5-6 day unit includes pedagogical strategies such as Internet treasure hunts, online interactive tutorials, cooperative group activities, problem solving, and hands-on activities. Students will gain real-world laboratory experience by working with micropipettes during a hands-on activity. They will learn how following proper protocol with minute samples is essential for accuracy and precision.
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