Abstract
Prolonged stressful experiences prior to adolescence have been linked to an increased risk of a multitude of neurological disorders, from depression and anxiety to schizophrenia and bipolar disorder. In particular, early life stress (ELS) has been shown to significantly impair adult hippocampal neurogenesis (AHN). While the long-term effects of early life stress are well studied, the underlying mechanisms through which ELS impairs AHN are still largely unknown. This paper reviews the current literature surrounding early life stress and AHN and discusses potential mediators that impact AHN during ELS including changes in telomere length, alterations in telomerase activity, and dysregulation of DNA methylation.
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