Abstract
The investigation of methodologies to obtain the metabolomic profile of blood serum from healthy individuals by LCMS/MS was performed by factorial planning and the number of molecular features as the system answer. Sample preparation, chromatographic and ionization source conditions were optimized, defining the best conditions to obtain the metabolomic profile of biofluids to be applied in future identification of potential tumor biomarkers.
Highlights
The investigation of methodologies to obtain the metabolomic profile of blood serum from healthy individuals by LCMS/MS was performed by factorial planning and the number of molecular features as the system answer
Ice biological fluids was performed in this work, where
- potential metabolites) of each analysis was used to evaluate the best analysis conditions, which will be employed for later use in the identification of potential tumor biomarkers
Summary
The investigation of methodologies to obtain the metabolomic profile of blood serum from healthy individuals by LCMS/MS was performed by factorial planning and the number of molecular features as the system answer. Metabolomics, the science that studies the metabolites in as the number of MF as well. A biological system, may provide identification of possible biomarkers, which help to determine diagnosis, prognosis Chart 1. Conditions for preparation of blood serum and prediction of diseases. Metabolic profile, which is the total set of metabolites present in a biological sample, and its comparison assay
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