Abstract
This study was designed to develop a topical skin-care cream water in oil (w/o) emulsion of 3% cucumber extracts versus its vehicle (Base) as control and evaluates its effects on skin-melanin, skin erythema, skin moisture, skin sebum and transepidermal water loss (TEWL). Hydroalcoholoc cucumber (Cucumis sativus) fruit extract was entrapped in the inner aqueous phase of w/o emulsion. Base containing no extract and a formulation containing 3% concentrated extract of C. sativus was formulated. The odour was adjusted with few drops of lemon oil. Both the base and formulation were stored at different storage conditions for a period of 4 weeks to predict their stability. Different stability parameters that is: Physical stability, centrifugation and pH were monitored at different time intervals. Both the base and formulation were applied to the cheeks of 21 healthy human volunteers for a period of 4 weeks. The expected pharmaceutical stability of creams was achieved from 4 weeks in vitro study period. Odour disappeared with passage of time due to volatilization of lemon oil. The base showed insignificant (p > 0.05) effects on all skin parameters except sebum that was not significant, whereas the formulation showed statistically significant (p ≤0.05) effects on skin sebum secretion. TEWL and erythema was increased while skin melanin and skin hydration level was decreased by formulation. However these effects were statistically insignificant (p > 0.05). The results showed a good stability over 4 weeks of observation period of both base and formulation and the formulation has anti sebum secretion, bleaching and moisturizing effects.
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