Abstract
The aim of the present study was to analyse the bioactive constituents and antioxidant potential of twenty-six medicinal plant extracts and their correlation for potential therapeutic insights. The total phenolic contents (TPC) and total flavonoid (TF) of plant extracts were determined by Folin–Ciocalteau reagent and aluminum chloride calorimetric assay, respectively. The extract was used to determine the antioxidant potential using different assay including total antioxidant activity, DPPH, and FRAP. The methanolic Terminalia chebula, Aloe vera, and Curcuma longa extracts showed the highest (p < 0.05) values of total phenolic content being 39.11, 38.80 and 38.14 mgGAE/g dw, respectively. The Ocimum tenuiflorum and Aloe vera extract had the highest (8.12 mg/g) total antioxidant capacity (p < 0.05) as compared to other extracts. The higher FRAP value (mMFe+2/g) was observed in methanolic extracts of Cinnamomum cassia, Moringa oleifera, and Withania somnifera and lowest was in water extract of Zizyphus zuzube. Correlation study indicated that TPC was found correlated with antioxidant capacity of plant extracts (TAC, r = 0.670, p < 0.01; FRAP, r = 0.501, p < 0.01; DPPH-IC50, r = −0.664, p < 0.01). The methanolic extracts from most of the plants had much higher TPC and antioxidant activities. The phenolic compounds are a primary contributor to the antioxidant efficacy among the medicinal plant species under investigation for potential therapeutic application. Overall, the current investigation demonstrated that the selected plants are potential sources for producing bioactive principles capable of scavenging free radicals.
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