Abstract
Utilizing natural products in drug discovery research are very comment practice and they lead to more than fifty percent of current medicines in the market. However, there are still needed in new therapeutic entities that can improve the efficiency of drugs against the enzymes. We are hoping this and future study lead to combat unmet needs among healthcare. Having said that, we would like to explore the coupling reactions to make bio-active natural products similar to capsaicin natural product and its chemical synthetic optimization before the its kinetic study. Currently, we are exploring two distinctive coupling reaction conditions to optimize the reaction condition and will present current status of our research project of coupling reaction. Furthermore, we would like to carry on enzymatic profile against resinaase HT enzyme to see how stable amide bond is.
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