Exploring 6-(substituted sulfonyl)imidazopyridines as a potential scaffold for the design of 5-HT6 ligands

Abstract

Cognitive dysfunction is a characteristic of various forms of dementia such as Alzheimer’s disease. We have focused on the 5-HT6 receptor in order to identify potent ligands. Herein we report the design of a novel series of 6-sulfonylimidazole derivatives substituted with an alkylamino chain at the 2- or 3-position, their synthesis, and their ability to interact with 5-HT6 receptors as evaluated in radioligand binding assays.