Abstract
Abstract This study investigates the highly sensitive detection capabilities of albumin using a defective one-dimensional photonic crystal. A novel biophotonic sensor is proposed featuring a cavity layer sandwiched between five identical periods of ternary layers composed of MgF₂/Si/PSi on each side. The transfer matrix method is employed to examine the sensing parameters based on the transmission characteristics of the proposed sensor. A defect mode emerges in the transmission spectrum when the sample infiltrates the cavity layer. The performance of the biosensor is evaluated by noting the shift in the position of the defect mode, which is dependent on the concentration and varies with the refractive index of the sample. The effects of variations in the incident angle and the thickness of the cavity layer for TM polarization are carefully investigated to achieve the highest sensor sensitivity. For the proposed structure, a high sensitivity of 2099.64 nm/RIU and a limit of detection of 9.698 × 10⁻⁷ are achieved, surpassing recent efforts in this research area. Additionally, the proposed device's affordability, real-time detection capabilities, and simple construction favour the development of an effective device using straightforward techniques.
Published Version
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