Exploration of inclusion complexes of neurotransmitters with β-cyclodextrin by physicochemical techniques

Abstract

Molecular assemblies of β-cyclodextrin with few of the most important neurotransmitters, viz., dopamine hydrochloride, tyramine hydrochloride and (±)-epinephrine hydrochloride in aqueous medium have been explored by reliable spectroscopic and physicochemical techniques as potential drug delivery systems. Job plots confirm the 1:1 host–guest inclusion complexes, while surface tension and conductivity studies illustrate the inclusion process. The inclusion complexes were characterized by 1H NMR spectroscopy and association constants have been calculated by using Benesi–Hildebrand method. Thermodynamic parameters for the formation of inclusion complexes have been derived by van’t Hoff equation, which demonstrate that the overall inclusion processes are thermodynamically favorable.