Abstract
Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated WikiPathways data has been added to the platform. This data includes information about biological interactions, such as stimulation and inhibition. The platform's Application Programming Interface (API) was extended with appropriate calls to reference these interactions. These new methods of the Open PHACTS API are available now.
Highlights
Targeting proteins to ideally restore normal biological processes is a common starting point in drug discovery[1]
Example workflows In order to demonstrate the basic use of the introduced Application Programming Interface (API) methods, we developed two workflows, available in the Supplementary Material
Summary While the calls identified here are simple calls, workflow tools make it possible to take advantage of the integrative nature of the Open PHACTS Discovery Platform (OPDP) to make API calls in succession
Summary
2. Yi-An Chen , National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan. Any reports and responses or comments on the article can be found at the end of the article. The most significant change in this revision is the addition of two simple example workflows. Supplementary File 1 was added which includes example result outputs for the two remaining API calls not shown in the main manuscript. Updated the Implementation section to clarify the WikiPathways RDF generation process. The summary section discusses creating more complex workflows and supported platforms and libraries. Updated the Methods section to specify what happens in the API call when an interaction direction is not specified. The Methods section explains how ontological interaction type information can be retrieved from the JSON returned by the API call
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
