Abstract
Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated WikiPathways data has been added to the platform. This data includes information about biological interactions, such as stimulation and inhibition. The platform's Application Programming Interface (API) was extended with appropriate calls to reference these interactions. These new methods of the Open PHACTS API are available now.
Highlights
Targeting proteins to ideally restore normal biological processes is a common starting point in drug discovery[1]
The importance and need of providing access to interaction information for real-world research questions was outlined in a recent Open PHACTS paper[8]
The Open PHACTS project was born out of the desire to integrate pharmacological data from multiple pre-competitive sources to efficiently address scientific questions that cannot be answered with single data sources[8]
Summary
Targeting proteins to ideally restore normal biological processes is a common starting point in drug discovery[1]. The Open PHACTS project was born out of the desire to integrate pharmacological data from multiple pre-competitive sources to efficiently address scientific questions that cannot be answered with single data sources[8]. It integrates data using linked data approaches[3] from chemical and biological sources such as ChEBI, ChEMBL, UniProt, and WikiPathways[6]. The OPDP did not previously include calls to access specific up- and downstream interaction effects This information is needed for questions related to drug repositioning and repurposing. We describe how to identify alternative targets in the same cellular pathway using OPDP against the WikiPathways data
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
