Explainable Machine Learning-Based Approach to Identify People at Risk of Diabetes Using Physical Activity Monitoring

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Objective: This study aimed to investigate the utilization of patterns derived from physical activity monitoring (PAM) for the identification of individuals at risk of type 2 diabetes mellitus (T2DM) through an at-home screening approach employing machine learning techniques. Methods: Data from the 2011–2014 National Health and Nutrition Examination Survey (NHANES) were scrutinized, focusing on the PAM component. The primary objective involved the identification of diabetes, characterized by an HbA1c ≥ 6.5% (48 mmol/mol), while the secondary objective included individuals with prediabetes, defined by an HbA1c ≥ 5.7% (39 mmol/mol). Features derived from PAM, along with age, were utilized as inputs for an XGBoost classification model. SHapley Additive exPlanations (SHAP) was employed to enhance the interpretability of the models. Results: The study included 7532 subjects with both PAM and HbA1c data. The model, which solely included PAM features, had a test dataset ROC-AUC of 0.74 (95% CI = 0.72–0.76). When integrating the PAM features with age, the model’s ROC-AUC increased to 0.79 (95% CI = 0.78–0.80) in the test dataset. When addressing the secondary target of prediabetes, the XGBoost model exhibited a test dataset ROC-AUC of 0.80 [95% CI; 0.79–0.81]. Conclusions: The objective quantification of physical activity through PAM yields valuable information that can be employed in the identification of individuals with undiagnosed diabetes and prediabetes.