EXPERIMENTS WITH HODGKIN'S DISEASE

Abstract

These experiments were made in an attempt to produce Hodgkin's disease in chimpanzees and rhesus monkeys. The apes were chosen because numerous attempts were made to produce this disease in lower animals. Feeding experiments and injections of gland extracts have been made on guinea-pigs, rabbits, ring tail and rhesus monkeys.1Certain hyperplasias have been produced, but it has been shown that the injection into animals of normal gland extracts causes a lymphatic hyperplasia. For a working basis the following premises were adopted: 1. Hodgkin's disease is a distinct clinicopathologic entity. 2. It belongs to the group of infectious granulomas and is of bacterial or protozoan origin. The results obtained were all negative, but it is believed that they should be recorded because the biologic similarity between chimpanzees and man make the findings of more significance in regard to the transmissibility of the disease by implantation of tissue. ANIMALS Before procuring