Abstract
Because of the recent interest aroused by Frei1 in demonstrating a diagnostic skin reaction to the whole extracts of glands in the virus disease lymphogranulomatosis (4th venereal disease) it was decided to observe the skin reactions on patients with Hodgkin's disease to the extracts of Hodgkin's diseased glands. Although the etiology of this disease remains obscure there are some2 who believe it may be due to a virus. Skin reactions can be obtained with the extract of skin lesions in small pox and vaccinia, a virus disease.The injection of filtrates of Hodgkin's glands has been used in treatment of the disease but the skin reactions to these filtrates have not been described adequately. Skin reactions to a preparation from Hodgkin's diseased glands were reported as negative in 3 cases by Fox and Farley.3Here we are further recording the negative results obtained in 11 patients with Hodgkin's disease treated by Roentgen ray in whom the diagnosis was assured by biopsy. All but one patient showed a skin rea...
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