Experimental study on treatment of cerebral vasospasm by intracisternal infusion of NC - PLGA microspheres

Abstract

Objective To study the therapeutic effects of intracisternal infusion of( nicardipine,NC) NC - PLGA microspheres solution on rabbits cerebral vasospasm (CVS) models.Method The primary SAH rabbit models were produced by injecting blood two times through cisterna magna.The CVS rabbit models were treated by intracisternal infusing of NC - PLGA microspheres and Nicardipine solution.The basal arteriospasm was observed with transcranial Doppler.The diameter of basilar artery was measured by cerebral angiography to evaluate the severity of CVS( P ＜ 0.01 ).The pathological changes of basilar artery walls were examined.Results Intracisternal infusion of NC - PLGA microspheres and Nicardipine could reduce the severity of CVS.And they could reduce the obvious morphological changes in the artierial wall of BA.Compared with intracisternal infusion of Nicardipine,using 25％ dose of intracisternal infusion of NC - PLGA microspheres could get the same effect.Conclusions The intracisternal infusion of NC - PLGA microspheres could reverse the severity of CVS and reverse the pathologic changement in the arterial wall.The therapeutic course is simple and complication rate is reduced.The technique with polymer should guide the therapy of cerebral vascular disease to some extent. Key words: Nicardipine; Intracisternal infusion; Vasospasm, intracranial