Experimental study on the effect of Coptis chinensis-Scutellaria baicalensis on prevention and treatment of ulcerative colitis and antioxidant capacity

Abstract

To explore the effect of Coptis chinensis-Scutellaria baicalensis on ulcerative colitis in mice and its antioxidant and anti-inflammatory effects in vitro. Sodium dextran sulfate (DSS) was used to induce acute ulcerative colitis in mice, lipopolysaccharide (LPS) was used to induce cell inflammation model, and ABTS and DPPH models were used to evaluate antioxidant capacity. The results showed that the drug had no significant effect on colitis, but cell experiments in vitro showed that the drug had significant anti-inflammatory effect and could scavenge ABTS and DPPH free radicals. Coptis chinensis-scutellaria baicalensis has anti-inflammatory and anti-oxidative effects.