Abstract
Objective To observe the anti-tumor effects of ultraviolet attenuated RH strain Toxoplasma on B16 melanoma in mice.Methods C57BL/6J mice were inoculated with 1×10~7 UV-attenuated RH strain T.gondii tachyzoites via peritoneal cavity.Seven days later,followed the second inoculation with same dose UV-attenuated tachyzoites.Mice were inoculated with B16 cells subcutaneously.The anti-tumor effects of UV-attenuated tachyzoites were observed by measuring the size and weight of tumor.The T cells subclass and NK cell activity were observed.Results TLA can obviously inhibit the B16 melanoma in mice.The size and weight of tumor in the mice immunized with attenuated tachyzoite were smaller than those of the control group(P ＜0.05),with the tumor inhibitory rate was 52.09%.The CD_3~+,CD_4~+,CD_8~+,CD_4~+/CD_8~+ and NK cytotoxic activity in experimental group are higher than these in the control group,and with a significant difference between two groups (P＜0.05).Conclusion UV-attanuated Toxoplasma can obviously inhibit the growth of B16 melanoma in mice. Key words: Toxoplasma gondii; UV-attenuated; mice melanoma; T lymphocyte subsets; NK cytotoxic activity
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