Experimental Study of Pathological and Some Immunological Aspect of Infection Pseudomonas aeruginosa bacteria and Exotoxin in Rabbits

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen which infect immunocompromised patients. bacteria produce large types of virulence factors that serves its pathogenicity. The exotoxin A is major toxic extracellular virulent factor produced by P. aeruginosa. To clear the effect of exotoxin A and P. aeruginosa , Bacteria suspension and Exotoxin A extraction were injected intraperitonially in four group of rabbits, the result show there was significant decrease in total leukocyte count in all groups specially after 7 days from injection of Bacteria suspension and Exotoxin A also there is increase in neutrophilia percentage is the same period, the bacteria suspension and toxin A are capable alone or in both to activated phagocytosis, and produce neutralizing antibodies and produce pathological and immunological effect in liver spleen , kidney and lung and this suggest that toxin A and P. aeruginosa bacteria can effect in some immunological and pathological aspect when injected in experimental rabbit.