Abstract
In the presented work we have attemptted to improve our understanding of the factors which lead to the formation of lipid membrane spatial heterogeneities, caused by mixtures of different lipids and/or transmembrane peptides. The demonstrated microscopic organization of lipid macrodomains in simple two-component lipid bilayers is of primary interest for structural biology where the origins and functions of lipid domains are currently intensively discussed. The phase behavior and structural domain formation approximates cell membrane behavior encountered in a native environment and points the way to an improved understanding of the physico-chemical properties of cell membranes and their associated physiology. In turn, directly observed and quantitatively analyzed peptide aggregation in phosphocholine membranes gives insights into the mechanisms behind protein-lipid interactions, the importance of which for the biological membrane functioning can hardly be overestimated.
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