Abstract
The glomerular basement membrane of rats was permanently labeled with deposits of silver nitrate ingested in drinking water. After labeling was achieved, silver nitrate ingestion was stopped. Thickening of the basement membranes was effected by normal aging of the rats or by the administration of aminonucleoside which induced chronic nephrosis. In both groups of rats new increments of glomerular basement membrane were free of silver, while the original lamina densa was diffusely and homogenously stippled by silver deposits. The new increments were located on the epithelial side of the basement membrane and were indistinguishable from the labeled portion. These experiments have demonstrated that glomerular basement membrane is a product of the epithelial cells, both in the normal processes of aging and in the pathological processes of aminonucleoside nephrosis.
Published Version
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