Abstract
ABSTRACT Objective: The paper uses artificial neural network images to explore the effects of aerobic exercise on the gamma rhythm of theta period in the awake hippocampal CA1 area of APP/PS1/tau mice and the low-frequency gamma rhythm of the sleep state hippocampal CA1 area SWR period. Methods: Clean grade 6-month-old APP/PS1/tau mice were randomly divided into quiet group (AS) and exercise group (AE), C57BL/6J control group mice were randomly divided into quiet group (CS) and exercise group (CE). The AE group and the CE group performed 12-week treadmill exercise, 5d/week, 60min/d, the first 10min exercise load was 12m/min, the last 50min was 15m/min treadmill slope was 0°. Eight-arm maze detection of behavioral changes in mice; multi-channel in vivo recording technology to record the electrical signals of the awake state and sleep state in the hippocampal CA1 area, MATLAB extracts the awake state theta period and sleep state SWR period, multi-window spectrum estimation method Perform time-frequency analysis and power spectral density analysis. Results: 12 weeks of aerobic exercise can significantly improve the working memory and reference memory of the AS group, increase the gamma energy in theta period of the awake hippocampus CA1 area and the low-frequency gamma energy in the sleep state CA1 area SWR period. Conclusions: Aerobic exercise can improve the neural network state of the AD model and increase the gamma energy in theta period of the hippocampus CA1 area, and the low-frequency gamma energy in the SWR period is one of the neural network mechanisms for its overall behavioral improvement. Level of evidence II; Therapeutic studies - investigation of treatment results.
Highlights
The neural system is accompanied by changes in the complex electrical activities of neurons in the high-level cognitive process
While improving the pathological characteristics of AD, can it improve the gamma rhythm that is closely related to cognitive function, and provide neuro-physiological mechanisms of cell function for aerobic exercise to improve the behavior of the AD model.[1]
P=0.000, partial η2=0.413, suggesting that genotype and exercise have no effect on theta period There is an interaction between the effects of gamma energy
Summary
The neural system is accompanied by changes in the complex electrical activities of neurons in the high-level cognitive process. The simultaneous release of a large number of neurons can cause regular changes in the local field post-synaptic potential, thereby forming neural network oscillations. Studies have shown that aerobic exercise can reduce Aβ deposition and tau protein hyperphosphorylation in the early (6-month-old) and advanced (9-month-old) AD models, reduce synaptic loss, increase synaptic plasticity, and improve cognitive function. While improving the pathological characteristics of AD, can it improve the gamma rhythm that is closely related to cognitive function, and provide neuro-physiological mechanisms of cell function for aerobic exercise to improve the behavior of the AD model.[1]
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