Abstract
A large number of models are now available for the investigation of skin wound healing. These can be used to study the processes that take place in a phase-specific manner under both physiological and pathological conditions. Most models focus on wound closure, which is a crucial parameter for wound healing. However, vascular supply plays an equally important role and corresponding models for selective or parallel investigation of microcirculation regeneration and angiogenesis are also described. In this review article, we therefore focus on the different levels of investigation of skin wound healing (in vivo to in virtuo) and the investigation of angiogenesis and its parameters.
Highlights
Sufficient blood supply plays one of the most important roles in the entire body for the maintenance of body homeostasis
We focus on the different levels of investigation of skin wound healing and the investigation of angiogenesis and its parameters
Many new in vitro and in virtuo models have been developed, which consider the pathogenesis of wound healing and the identification of new drugs or biomarkers
Summary
Sufficient blood supply plays one of the most important roles in the entire body for the maintenance of body homeostasis. In the wound healing of the skin, the restoration of the blood supply over the entire period is an indispensable process. Since a wide variety of wound healing models have been described, this article focuses on the processes involved in vascularization and microcirculation in the skin and presents new results, models and methods for their analysis. It is the aim of this review to summarize established and new in vivo and in vitro models for wound healing, to illustrate their advantages and disadvantages and to describe the key points of implementation of the respective models
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
